RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike on an hidden munitions depot in Syria used by the Islamic State group (IS), according to the UK's MoD.
The site, pinpointed through surveillance, was thought to be containing munitions and bombs, the statement said, and was located in mountainous terrain just above the historic site of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to target a series of approach shafts down to the site... initial indications indicate the strike was effective," the MoD said.
There was no sign of any civilian casualties in the attack conducted Saturday night and each participating jet made a safe return, the ministry further stated.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as ISIS - enforced militant control over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and determination to stand shoulder to shoulder with our partners, to stamp out any re-emergence of IS and their violent and radical beliefs in the area," UK Defence Secretary John Healey said.
British military aircraft have conducted patrols over Syrian airspace to "forestall any attempted comeback" of the group after its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank every member of British forces involved in this mission for their professionalism and their valour," the Defence Secretary commented. "Including them were thousands of British troops on duty over the holidays. This action, to remove terrorist threats who endanger our way of life, shows how our armed forces are prepared to act, all year round, ensuring Britain's security at home and strong abroad."
In December, the United States armed forces conducted what it described as a "major assault" on Islamic State objectives in the country, subsequent to an attack resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The U.N. reports IS still boasts between 5,000 and 7,000 militants in Iraq and Syria.